Primary progressive multiple sclerosis: progress and challenges
نویسندگان
چکیده
منابع مشابه
Primary progressive multiple sclerosis: progress and challenges.
Primary progressive multiple sclerosis (MS) has long been recognised as presenting great difficulties to our management of what is increasingly a treatable neurological disease. Here we review some basic and clinical aspects of primary progressive MS, and describe how the disorder in fact offers powerful insights and opportunities for better understanding multiple sclerosis, and from a practica...
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About 10-15% of patients with multiple sclerosis (MS) present with gradually increasing neurological disability, a disorder known as primary-progressive multiple sclerosis (PPMS). Compared with relapse-onset multiple sclerosis, people with PPMS are older at onset and a higher proportion are men. Inflammatory white-matter lesions are less evident but diffuse axonal loss and microglial activation...
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M ultiple sclerosis (MS) remains an enigmatic disease. Not only is the cause unknown, but the last decade of work has led to uncertainty concerning some of the previously, most strongly held, convictions about the disease. Recently, attention has shifted from understanding demyelination to understanding how axons are injured. It has been attractive to hypothesise that axonal damage occurs with ...
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Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system and a major cause of chronic neurological disability in young adults. Primary progressive MS (PPMS) constitutes about 10% of cases, and is characterized by a steady decline in function with no acute attacks. The rate of deterioration from disease onset is more rapid than relapsing remitting...
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BACKGROUND AND PURPOSE Potential differences between primary progressive and relapsing remitting multiple sclerosis are the subject of ongoing controversial discussions. The aim of this work was to determine whether and how primary-progressive and relapsing-remitting multiple sclerosis subtypes differ regarding conventional MR imaging parameters, cerebral iron deposits, and their association wi...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2013
ISSN: 0022-3050,1468-330X
DOI: 10.1136/jnnp-2012-304140